Interfacial Denaturation at the Droplet Simplifies the Formation of Drug‐Loaded Protein Nanocapsules to Enhance Immune Response of Cells

Pottanam Chali, S. and Kang, J. and Fichter, M. and Speth, K. R. and Mailänder, V. and Landfester, K. (2024) Interfacial Denaturation at the Droplet Simplifies the Formation of Drug‐Loaded Protein Nanocapsules to Enhance Immune Response of Cells. [Publications (Pre-joining)]

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Abstract

Nanocapsules enable multicomponent encapsulation of therapeutic cargoes with high encapsulation content and efficiency, which is vital for cancer immunotherapy. In the past, chemical crosslinking is used to synthesize nanocapsules, which can impede the regulatory approval process. Therefore, a new class of protein nanocapsules is developed by eliminating the need for chemical crosslinking by utilizing protein denaturation through a process that is referred to as “baking at the droplet interface”. Such protein nanocapsules with antigens incorporated in the shell and a combination of encapsulated drugs showed an enhancement in the immune response of cells.

Item Type:	Publications (Pre-joining)
Authors:	Pottanam Chali, S. and Kang, J. and Fichter, M. and Speth, K. R. and Mailänder, V. and Landfester, K.
Document Language:	Language English
Subjects:	Natural Sciences Natural Sciences > Life sciences; biology > Biochemistry
Divisions:	Azim Premji University - Bengaluru > School of Arts and Sciences
Full Text Status:	Restricted
URI:	http://publications.azimpremjiuniversity.edu.in/id/eprint/6645
Publisher URL:	https://doi.org/https://doi.org/10.1002/advs.20240...

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