Hierarchical size scaling during multicellular growth and development

Uppaluri, Sravanti and Weber, Stephanie C. and Brangwynne, Clifford P. (2016) Hierarchical size scaling during multicellular growth and development. Cell Reports, 17 (2). pp. 345-352. ISSN 22111247

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Abstract

Multicellular organisms must regulate their growth across the diverse length scales of biological organization, but how this growth is controlled from organelle to body, while coordinating interdependent functions at each scale, remains poorly understood. We utilized the C. elegans worm intestine as a model system to identify distinct allometric scaling laws, revealing that the growth of individual structures is differentially regulated during development. We show that the volume of the nucleolus, a subcellular organelle, is directly proportional (isometric) to cell size during larval development. In contrast to findings in a variety of other systems, the size of the nucleus grows more slowly and is hypoallometric to the cell. We further demonstrate that the relative size of the nucleolus, the site of ribosome biogenesis, is predictive of the growth rate of the entire worm. These results highlight the importance of subcellular size for organism-level function in multicellular organisms.

Item Type:	Article
Authors:	Uppaluri, Sravanti and Weber, Stephanie C. and Brangwynne, Clifford P.
Document Language:	Language English
Subjects:	Natural Sciences
Divisions:	Azim Premji University - Bengaluru > School of Arts and Sciences
Full Text Status:	Public
URI:	http://publications.azimpremjiuniversity.edu.in/id/eprint/7336
Publisher URL:	https://doi.org/10.1016/j.celrep.2016.09.007

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